Skip to main content
. 2020 Mar 13;8:131. doi: 10.3389/fcell.2020.00131

FIGURE 8.

FIGURE 8

Changes in the gut microbiota in collagen-induced arthritis (CIA), methotrexate (MTX), and human umbilical mesenchymal stem cells (HUMSCs) groups. The alpha diversity, beta diversity, and the typical bacterial genera and species were obtained by 16S sequencing. (A–C) Bar plots showing the mean Chao1 and Shannon diversity indices and the operational taxonomic units (OTUs) of all groups. (D) Relative abundance of the top 10 most abundant phyla in each sample. (E) The differences in the intestinal microbial communities among the groups were assessed by partial least square discriminant analysis (PLS-DA). (F) Taxonomical differences among the groups at the different levels. The dominant bacteria were determined by Lefse analyses. (G) Relative abundances among the groups at the genus and species levels N = 8. The data in panels (A–C) are presented as the medians [interquartile range (IQR)]. #P < 0.05 compared with the Control group, ##P < 0.01 compared with the Control group, *P < 0.05 compared with the CIA group, **P < 0.01 compared with the CIA group.