TABLE 2.

Percentages of Tregs, Th17, and B cells in gut-associated lymphoid tissues (N = 8).

Tissues	Group	Cell type
		Tregs (%)	Th17 cells (%)	B cells (%)
Mesenteric lymph node	Control	6.07 ± 2.21	0.20 ± 0.12	31.50 ± 3.34
	CIA	5.41 ± 1.31	0.34 ± 0.05#	32.82 ± 4.18
	MTX	7.06 ± 0.80*	0.32 ± 0.08	34.34 ± 3.73
	HUMSCs	7.27 ± 0.73*	0.24 ± 0.05*	35.20 ± 5.43
Peyer’s patch	Control	10.77 ± 1.62	0.67 ± 0.39	44.80 ± 5.74
	CIA	10.86 ± 1.79	1.17 ± 0.90#	39.23 ± 4.81#
	MTX	8.29 ± 1.90#*	0.46 ± 0.27*	55.06 ± 4.63#**
	HUMSCs	14.81 ± 3.09##*	0.48 ± 0.18*	54.12 ± 6.82#**
Lamina propria lymphocyte	Control	27.98 ± 2.89	2.57 ± 1.46	37.37 ± 2.96
	CIA	21.03 ± 5.41#	8.30 ± 2.02#	31.92 ± 3.85#
	MTX	31.08 ± 9.66*	3.46 ± 0.89**	46.26 ± 11.39*
	HUMSCs	28.75 ± 4.15*	3.04 ± 1.42**	49.00 ± 15.89*

The data are presented as the mean ± SEM. ^#P < 0.05 compared with the Control group, ^##P < 0.01 compared with the Control group, *P < 0.05 compared with the CIA group, **P < 0.01 compared with the CIA group. Tregs, T regulatory cells; Th17, T helper 17; CIA, collagen-induced arthritis; MTX, methotrexate; HUMSCs, human umbilical mesenchymal stem cells.