. Author manuscript; available in PMC: 2020 Aug 5.

Published in final edited form as: Dev Cell. 2019 Jun 6;50(3):367–380.e7. doi: 10.1016/j.devcel.2019.05.017

Table 1:

Summary of biochemical and functional comparison of NEUROG3 mutations to WT NEUROG3.

NEUROG3 Mutation	Protein Stability	E47 dimerization	DNA binding		Endocrine rescue
NEUROG3 Mutation	Protein Stability	E47 dimerization	High affinity	Low affinity	Pancreas	HIO
WT	+++	+++	+++	+++	+++	+++
E28X	−	−	−	−	−	−
R93L	+++	+++	++	+	++	++
R107S	++	+	+++	+	++	++
L135P	+++	−	−	−	−	−
E123X	+	−	−	−	−	−
S171fsX68	++++	+	+	++	++	−