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. Author manuscript; available in PMC: 2020 Jul 12.
Published in final edited form as: ACS Infect Dis. 2019 May 14;5(7):1139–1149. doi: 10.1021/acsinfecdis.9b00010

Figure 1. Carboxamide compound BNBC activates cGAS-STING pathway in a functional human STING-dependent manner.

Figure 1.

(A) Chemical structure of BNBC. (B) Activation of ISG54 promoter activities by BNBC were determined in HepAD38/cGAS-STING/ISG54Luc, HepAD38/cGAS-STINGΔC/ISG54Luc cells and HepG2/STING/ISG54Luc cells. Luciferase activity was measured at 4 h post treatment and expressed as fold of induction (mean ± standard deviation, n=3). * indicates p<0.05 compared to mock treated control. (C) Cytotoxicity was determined in HepAD38/cGAS-STING/ISG54Luc and HepAD38/cGAS-STINGΔC/ISG54Luc cells after 4 h treatment and expressed as percent of mock treated control (mean ± standard deviation, n=3).