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. Author manuscript; available in PMC: 2020 Jul 12.
Published in final edited form as: ACS Infect Dis. 2019 May 14;5(7):1139–1149. doi: 10.1021/acsinfecdis.9b00010

Figure 5. Activity of BNBC in human PBMCs.

Figure 5.

(A) PBMCs freshly isolated from human blood were treated with indicated concentration of BNBC for 6 h and followed by detection of cytokine mRNAs by qRT-PCR. The levels of cytokine mRNA were expressed as fold of induction (mean ± standard deviation, n=4). (B) PBMCs freshly isolated from human blood of additional three healthy donors were treated with 15 μM of 2’3’-cGAMP, 60 μM of BNBC or G10 for 6 h. The mRNAs of IFN-β, IL-28A, IL-29 and TNFα were detected by qRT-PCR and expressed as fold of induction (mean ± standard deviation, n=3). * indicates p<0.05 compared to mock treated control.