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. Author manuscript; available in PMC: 2020 Jul 12.
Published in final edited form as: ACS Infect Dis. 2019 May 14;5(7):1139–1149. doi: 10.1021/acsinfecdis.9b00010

Table 2.

Structure-activity relationship study of BNBC

Cmpd* BNBC 57093Z 57057Z 57071Z 57076 59011Z 59016Z
Structure graphic file with name nihms-1566658-t0002.jpg graphic file with name nihms-1566658-t0003.jpg graphic file with name nihms-1566658-t0004.jpg graphic file with name nihms-1566658-t0005.jpg graphic file with name nihms-1566658-t0006.jpg graphic file with name nihms-1566658-t0007.jpg graphic file with name nihms-1566658-t0008.jpg
1MinEC5X
(μM)		 2.2 2.5 > 200 2.6 > 200 > 200 50
1Maximum induction (fold) 20.5 28.0 - 17.3 - - 7.8
2CC50 (μM) > 200 > 200 > 200 > 200 > 200 > 200 > 200
*

compound.

1

Luciferase activity was determined in HepG2/STING/ISG54Luc cells and expressed as Minimum Effective Concentration to induce 5-fold luciferase activity or maximum fold of luciferase induction.

2

Cytotoxicity was determined in HepG2/STING/ISG54Luc cells by MTT assay.