Table 1.
Clinical features of patients, pathological and Immunohistological profile of metastatic and localized SPNs.
|
Localized SPN (N = 31) |
Metastatic SPN (N = 4) |
|
|---|---|---|
| Clinical Features | ||
| Gender | ||
| Male | 3 | 0 |
| Female | 28 | 4 |
| Age, y | 33.8 | 35.5 |
| Symptoms at Presentation | ||
| Abdominal pain | 13 | 2 |
| Back pain | 3 | 0 |
| Weight loss | 6 | 0 |
| Incidental | 11 | 0 |
| Fever of unknown origin | 2 | 0 |
| Tumor Location | ||
| Head | 7 | 0 |
| Tail | 15 | 3 |
| Body/neck | 9 | 1 |
| Tumor size (range) | 5.20 cm (0.9–14) | 8.12 cm (7–9) |
| Type of Surgery | ||
| Enucleation | 2 | 0 |
| Distal pancreatectomy | 22 | 3 |
| Pancreaticoduodenectomy | 4 | 1 |
| Adjacent organ invasion | 2 | 0 |
| Pathological and Immunohistological Profile | ||
| Resection margin | Free = 31 | Free = 3, unknown = 1 |
| Microscopic Malignant Features | ||
| Cellular atypia | 6 | 2 |
| Capsule invasion | 8 | 1 |
| Peripancreatic fat invasion | 4 | 1 |
| Perineural invasion | 2 | 1 |
| Lymphovascular invasion | 3 | 1 |
| Lymph node metastases | 0 | 0 |
| Immunohistological Staining (Positive/Tested) | ||
| Beta catenin | 17/17 | 2/2 |
| CD-10 | 20/22 | 1/1 |
| Neuron-specific enolase | 14/14 | 1/1 |
| Chromogranin A | 4/28 | 0/3 |
| Synaptophysin | 17/25 | 3/3 |
| Progesterone | 10/17 | 1/3 |
| Vimentin | 18/18 | 2/2 |
| KI-67 ≥ 3% | 2/23 (5%, 10%) | 1/3 (3%) |
| Cytokeratin | 10/12 | 3/3 |