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Key regulators orchestrate metabolic plasticity and stemness features in CSCs. Critical transcription factors such as MYC, HIF-1α, and p53 not only govern metabolic plasticity and redox homeostasis in CSCs but also serve as coordinators in regulating the stemness traits and differentiation capabilities of CSCs. Activation is represented by red lines and suppression is denoted by green lines. (A color version of this figure is available in the online journal.)
