Figure 1.

PHB1’s roles in different cellular compartments. PHB1 can exert different functions depending on its subcellular localization. Plasma membrane-bound PHB1 activates multiple signaling pathways and has been shown to function as a receptor for some viruses and bacteria in other cell types. In hepatocytes it has been shown to facilitate HCV entry. Whether hepatocyte membrane-bound PHB1 also binds to other viruses or bacteria is unknown. Nuclear PHB1 regulates transcription and cell proliferation by interacting with different transcription factors involved in the cell cycle. In the mitochondria, PHB1 interacts with PHB2 to form the PHB complex and regulate processes essential for normal mitochondrial function. (A color version of this figure is available in the online journal.)