Figure 1.

Strategies for non-invasive biomarker discovery. (a) Strategies for non-invasive biomarker discovery. Biomarkers can be uncovered and validated using two different methodologies: a hypothesis-driven or a hypothesis-free “omics” approach. (b) Hypothesis-driven approach. Using existing knowledge from different sources illustrated here, candidate biomarkers are hypothesized then subject to testing. (c) Screening “omics’’ approach. Diverse high-throughput technologies, such as those indicated here, are used to uncover candidate endometriosis biomarkers by comparing patient tissue to controls.