Table 2.

Univariate and multivariate factors predicting OS for sRCC

		Univariate OS Analysis			Multivariable OS Analysis
Covariate	Category (Ref.)	HR	95% CI	p-value	HR	95% CI	p-value
Age at Nephrectomy	Age (Years)	1.0049	0.99–1.02	0.5392
Gender	Male (Ref. Female)	1.0444	0.69–1.57	0.8356
Karnofsky Performance Status	<80 (Ref. ≥80)	1.3476	0.78–2.32	0.2822
Smoking Status	Smoking History (Ref. Non-smoker)	1.0598	0.76–1.48	0.7327
Prior Systemic Therapy	Pretreated (Ref. Treatment naïve)	0.8359	0.45–1.55	0.5691
Tumor Size	Maximum Size (cm)	1.0320	0.99–1.07	0.1130
Tumor Stage	T3/T4 (Ref. T1/T2)	1.5475	0.94–2.55	0.0855
Histology	Non-Clear Cell (Ref. Clear Cell)	1.5196	1.06–2.17	0.0216	1.6116	1.10–2.35	0.0134
Metastatic Focality	Multifocality (Ref.Unifocality)	1.6257	1.15–2.31	0.0066	1.265	0.84–1.91	0.2623
Retroperitoneal Adenopathy	Involved (Ref. Not Involved)	1.8286	1.29–2.60	0.0008	1.5211	1.03–2.25	0.0350
Supra-diaphragmatic Adenopathy	Involved (Ref. Not Involved)	1.1621	0.78–1.74	0.4664
Lung Metastases	Involved (Ref. Not Involved)	1.4308	1.02–2.01	0.0393	1.4974	1.05–2.14	0.027
Appendicular Bone Metastases	Involved (Ref. Not Involved)	0.9472	0.61–1.48	0.8119
Axial Skeleton Metastases	Involved (Ref. Not Involved)	0.9532	0.64–1.41	0.8117
Liver Metastases	Involved (Ref. Not Involved)	1.9121	1.21–3.02	0.0055	1.6383	1.02–2.63	0.0413
Rare Site Metastases	Involved (Ref. Not Involved)	1.1763	0.82–1.69	0.3833