Table 1.

Distribution and frequency of known somatic mutations in different histotypes of thyroid cancer.

	PTC	FTC	PDTC	ATC	MTC
AKT	1% (5)	1-2.6% (6, 7)	–	0–3% (8, 9)	–
BRAF	61.7% (5)	1.7% (7)	19% (8)−33% (9)	19–45% (8–10)	–
DICER1	2.7% (5)	5.1% (6)	–	1.1% (9)	–
EIF1AX	1.5% (5)	5.1% (6)	10% (9)	9% (8)	0.6% (11)
HRAS	2% (5)	7% (7)	5% (9)	6% (8)	9.3–15.8% (11)
KRAS	1.26% (5)	4% (7)	2% (9)	0–5% (8, 9)	3.0–6.2% (11)
NRAS	6% (5)	17% (12)−57% (6)	21% (9)	18% (8)	0.6–1% (11)
PAX8-PPARγ	0.8% (5)	12% (13)−53% (14)	4% (9)	0 (8)	–
PI3KCA	–	5.5% (7)	2% (9)	18% (8)	–
PTEN	1% (5)	7.1% (7)	4% (9)	15% (8)	1% (11)
RET	–	–	–	–	55.8% (11)
RET/PTC	6.8% (5)	0 (7)	14% (9)	0 (8)	Very rare (15)
SWI/SNF	–	–	6% (9)	18–36% (8, 9)	–
TERT promoter	9.4% (5)	–	33–40% (8, 9)	43–73% (8–10)	–
TP53	6% (5)	5.1–9.7% (6, 7)	0–8% (8, 9)	43–78% (8–10)	1.2% (11)
TSHR	2% (5)	10.3% (7)	2% (9)	6% (8)	0.6% (11)