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. 2020 Mar 20;8:38. doi: 10.1186/s40478-020-00910-z

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Electrophysiological evaluation of hippocampal dentate gyrus synaptic plasticity in HMBS-deficient mice. a Schematic depiction of the placement of the electrodes for LTP recordings. b LTP of fEPSP after high frequency stimulation and c representative traces in HMBS-deficient (KI) and WT mice. d Input-output recordings and e paired-pulse inhibition of fEPSP to maximum fEPSP. All values are presented as mean ± SEM; n = 8–12 per genotype. Statistical significances displayed reflect results of repeated measure mixed model ANOVA. *p < 0.05; HMBS, hydroxymethylbilane synthase; LTP, long-term potentiation; fEPSP, field excitatory postsynaptic potential, MPP, medial perforant path; DG, dentate gyrus