Table. 1.
a) Degree of substitution and physicochemical properties of HPMCAS grades, b) Extrusion process temperature and torque values for pure polymer and formulations
| HPMCAS Grade |
Acetyl- (%) |
Succinoyl- (%) |
Methoxyl- (%) |
Hydroxy propoxy- (%) |
Tg (°C) | pH solubility |
MW | Melt Viscosity (mPa.S) |
|---|---|---|---|---|---|---|---|---|
| LG | 5-9 | 14-18 | 20-24 | 5-9 | 119 | 5.5-6 | 114,700 | 2.4-3.6 |
| MG | 7-11 | 10-14 | 21-25 | 5-9 | 120 | 6-6.5 | 103,200 | 2.4-3.6 |
| HG | 10-14 | 4-8 | 22-26 | 6-10 | 122 | >6.8 | 75,100 | 2.4-3.6 |
| Name | Torque values (in Nm) at different extrusion temperatures (° C) | |||||||
| 130 | 140 | 150 | 160 | 170 | 180 | 190 | ||
| HPMCAS LG | Exceeded instrument maximum (>12 Nm) | > 10.2 | 7.8-8.5 | 6.6-7.2 | ||||
| HPMCAS MG | >12 | >12 | >12 | > 10 | 8.0-8.4 | 6.7-7.2 | NA | |
| HPMCAS HG | >12 | >12 | >12 | > 10 | 7.2-7.6 | 6-6.4 | NA | |
| HPMCAS LG-NFD | >12 | 10.2-10.5 | 7.0-7.2 | 5.5-6.1 | 5.0-5.6 | 4.8-5.3 | NA | |
| HPMCAS MG-NFD | >12 | 10.0-10.2 | 6.6-6.8 | 5.0-6.0 | 4.9-5.4 | 4.6-5.0 | NA | |
| HPMCAS HG-NFD | >12 | 9.5-9.8 | 5.8-6.1 | 4.8-5.4 | 4.3-4.6 | 3.6-4.0 | NA | |
| HPMCAS LG-EFZ | 5.4-6.0 | 4.3-4.4 | 3.2-3.6 | NA | NA | NA | NA | |
| HPMCAS MG-EFZ | 5.2-5.4 | 3.7-3.8 | 3.2-3.4 | NA | NA | NA | NA | |
| HPMCAS HG-EFZ | 4.6-4.8 | 3.4-3.7 | 3.0-3.2 | NA | NA | NA | NA | |