Fig. 2.

Evaluation of prognostic accuracy. Predicted survival from various prognostic classifiers vs observed progression free survival with the Brier score (top row, a-c) or tAUC (bottom row, d-f). Figures display means + − 2SD evaluated across the 10 cross-validation repetitions. The prognostic classifiers include: multivariate Cox regression models using either age (CoxAge), IPI (CoxIPI), miRNA expression (CoxMIR), or miRNA expression combined with IPI score (CoxMIRIPI), and random survival forest models using miRNA expression (RSFMIR) or miRNA expression in combination with IPI (RSFMIRIPI). Time in years. Figure was constructed using the R packages ggplot2 v3.2.1 and gridExtra v2.3. ABC, activated B-cell-like; GCB, germinal center B-cell-like; IPI, international prognostic index; MIR, microRNA panel; PFS, progression-free survival; RSF, random survival forest; tAUC, time-varying are under the ROC curve