Table 3.

Candidate miRNAs

Probe ID (HG-U133)	miRNA	Drug sensitivity	Annotation grade
232504_at	miR-146a	↓ Cyc, ↑ Vin	A
238225_at	miR-146a	↓ Cyc, ↑ Vin	B
229437_at	miR-155	↓ Rtx, ↑ Dox, ↑Vin	A
220990_s_at	miR-21	↑ Vin	A
229417_at	miR-21	↑ Vin	E
235317_at	miR-23a~miR-27a~miR-24-2	↑ Dox, ↑ Vin	B
1555847_a_at	miR-23a~miR-27a~miR-24-2	↑ Dox, ↑ Vin	A
235571_at	miR-34a	↑ Dox, ↑ Vin	A
1557342_a_at	let-7b	↑ Vin	A
241464_s_at	let-7b	↑ Vin	B
227488_at	miR-503	↓ Rtx	B

Differentially expressed miRNAs detected by HG-U133 Plus 2.0 probes were selected as candidate miRNAs. The list consisted of 11 probe sets detecting 9 miRNAs. The annotation grade was assessed by NetAffx (Affymetrix) a transcript assignment pipeline creating a relationship between GeneChip probe sets and current transcript record. The transcript assignment grades fall into five categories A-E that describe the quality of the direct evidence. Grade A is a matching probe set having nine or more probes matching transcript mRNA. Grade B transcript assignments have partial overlap between transcripts and target sequence. Grade E is given when no transcript is found. Abbreviations: ↑ and ↓ defines up- and downregulation, respectively, in drug sensitive cell lines. Cyc, cyclophosphamide; Dox, doxorubicin; Rtx, rituximab; Vin, vincristine