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. 2020 Mar 20;21:71. doi: 10.1186/s12931-020-1331-4

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© The Author(s). 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 3 — Effects of MSC-exo on MCT-induced endothelial-to-mesenchymal transition. a Representative immunofluorescence staining with a-SMA (Red) and the cell nuclei were labeled with DAPI (blue) in the pulmonary arterioles using a light microscope at a × 400 magnification. b Comparative analysis of non-muscularized vessels, partially muscularized vessels, and fully muscularized vessels. c Protein expression of CD31 and a-SMA analysis by western blot in lungs. d Detection and comparative analysis of the protein expression of Wnt5a, β-catenin and cyclin D1. n = 5 rats per group; P < 0.05, t-test; the data are present as mean ± SD; ^*MCT or ^*MSC-CM vs. control; ^#MSC-exo vs. MCT group; scale bar = 100 μm