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. 2020 Mar 19;8:35. doi: 10.1186/s40478-020-00903-y

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© The Author(s) 2020

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Transcriptional profile of the human choroid plexus in progressive MS. a Volcano plot of statistical significance against fold change between CP of progressive MS cases (n = 6) and that of controls (n = 6). Each dot represents a gene. Genes considered to be significantly differentially expressed (adjusted p-value < 0.05) are depicted in turquoise. b Heatmap of differentially expressed genes (adjusted p-value < 0.05) between progressive MS and control CP. Samples are ordered by sample name. c 100% stacked chart for EPAS1 displaying the percentages of each splice variant in progressive MS and control CP. Samples are ordered by sample name. Splice variant IDs are the versions from Ensembl Human GRCh38 build 97 as of submission