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. Author manuscript; available in PMC: 2021 Jan 23.
Published in final edited form as: Cell. 2019 Dec 26;180(2):340–347.e9. doi: 10.1016/j.cell.2019.12.003

Figure 1. Function validation and structure determination of hKCNQ1EM-KCNE3-CaM complex.

Figure 1.

(A) Voltage family current trace of the hKCNQ1EM-KCNE3-CaM complex recorded in CHO cells (top) and the I-V curve of the channel activation plotted at the time point indicated by the black arrow.

(B) Side and top view of the hKCNQ1EM-KCNE3-CaM cryo-EM density map. KCNQ1, KCNE3 and CaM are colored in blue, red and orange, respectively.

(C) Structure model of the hKCNQ1EM-KCNE3-CaM complex oriented and colored as in (B).