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. 2020 Mar 13;11:223. doi: 10.3389/fphar.2020.00223

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Copyright © 2020 Wu, Yang, Wang, Cao, Zhao, Li, Xing and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Berberine significantly alters the composition of gut microbiota in HFD-induced atherosclerosis mice. (A and B) Diversity of the gut microbiome assessed by Chao1 and Shannon indices among the four groups. (C) Principal Coordinate Analysis (PCoA) based on the Bray Curtis distance algorithm. (D) Taxonomic composition of each group at the phylum level. (E) Taxonomic composition at the genus level. (F and G) Relative abundance of Proteobacteria and Actinobacteria in the one-way ANOVA bar plot on the phylum level. ^∗ p < 0.05, ^∗∗ p < 0.01.