Figure 1.

In all patients, arterial systolic (A) and diastolic (B) blood pressure and heartrate (C) were measured at the given time-points before, during and after start of the 45 min Fasudil infusion. In patient A (left column), this monitoring was done regularly on the first 3 days of infusion. Here, all data are shown in the graphs. For patients B (middle column) and C (right column) monitoring was conducted during every infusion. Here, only the data from the morning infusion of every fifth day are given. While patient A and B were hypertonic especially at the beginning of each infusion, no significant or clinically relevant changes in blood pressure or heart rate were noted.