Table 1.
Incremental cost-effectiveness ratios for the treatment strategies*
| Strategy | Cost | Incremental cost | Effectiveness | Incremental effectiveness | Incremental cost/effectiveness | Cost/effectiveness | Dominance |
|---|---|---|---|---|---|---|---|
| Excluding dominated (Strategy 2) | |||||||
| Strategy 1 | 1695.865 | — | 8.570992 | — | — | 197.861 | Undominated |
| Strategy 3 | 12 118.17 | 10 422.31 | 8.590681 | 0.019688 | 529 365.8 | 1410.618 | Undominated |
| All | |||||||
| Strategy 1 | 1695.865 | — | 8.570992 | — | — | 197.861 | Undominated |
| Strategy 3 | 12 118.17 | 10 422.31 | 8.590681 | 0.019688 | 529 365.8 | 1410.618 | Undominated |
| Strategy 2 | 12 224.17 | 106.001 | 8.583273 | −0.00741 | −14 308.9 | 1424.186 | Absolutely dominated |
| All referencing common baseline | |||||||
| Strategy 1 | 1695.865 | — | 8.570992 | — | — | 197.861 | Undominated |
| Strategy 3 | 12 118.17 | 10 422.31 | 8.590681 | 0.019688 | 529 365.8 | 1410.618 | Undominated |
| Strategy 2 | 12 224.17 | 10 528.31 | 8.583273 | 0.01228 | 857 336.1 | 1424.186 | Absolutely dominated |
| All by increasing effectiveness | |||||||
| Strategy 1 | 1695.865 | — | 8.570992 | — | — | 197.861 | Undominated |
| Strategy 2 | 12 224.17 | — | 8.583273 | — | — | 1424.186 | Absolutely dominated |
| Strategy 3 | 12 118.17 | — | 8.590681 | — | — | 1410.618 | Undominated |
*
When one strategy is both less effective and more expensive, that strategy is absolutely dominated by the other strategies. Extended dominance occurs when the incremental cost-effectiveness ratio for a given treatment alternative is higher than that of the next, more effective, alternative. RT = radiation therapy; Strategy 1 = no testing, no RT; Strategy 2 = test all, RT only for elevated risk; Strategy 3 = no testing, RT for all.