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. 2020 Mar 13;10:294. doi: 10.3389/fonc.2020.00294

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Copyright © 2020 Li, Peng, Yang, Chen, Gu, Qian, Ji, Wang, Zhang, Tang and Sun.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The prognostic value of miR-1224-5p and SP1 in patients with CRC. (A,B) Comparison of overall survival (OS) and disease-free survival (DFS) between patients with high expression of miR-1224-5p and low expressing cases in CRC via Kaplan–Meier analysis. (C,D). Comparison of OS and DFS between patients with high expression of SP1 and low expressing cases in CRC. (E,F). Comparison of OS and DFS between four subgroups of CRC patients (subgroup I: high miR-1224-5p and low SP1; subgroup II: high miR-1224-5p and high SP1; subgroup III: low miR-1224-5p and low SP1; subgroup IV: low miR-1224-5p and high SP1). Log-rank test was used to determine statistical significance: *p < 0.05.