Table 1:
Baseline comparison of recipients of hepatitis C antibody positive kidneys versus recipients of hepatitis C antibody negative kidneys in the direct acting antiviral era. Continuous covariates are expressed as mean (standard deviation) and categorical covariates are expressed as count (percentage).
| HCV Ab Negative(n=1218) | HCV Ab Positive(n=1130) | P-value | |
|---|---|---|---|
| Recipient Age | 56.6 (10.3) | 59.6 (7.5) | <0.001 |
| Recipient Ethnicity | <0.001 | ||
| Caucasian | 317 (26.0%) | 267 (23.6%) | |
| African American | 627 (51.5%) | 696 (61.6%) | |
| Hispanic | 191 (15.7%) | 125 (11.1%) | |
| Asian | 48 (3.9%) | 23 (2.0%) | |
| Other | 35 (2.9%) | 19 (1.7%) | |
| Female Recipient | 373 (30.6%) | 241 (21.3%) | <0.001 |
| Recipient BMI | 27.7 (4.9) | 27.7 (4.9) | 0.880 |
| Recipient Diabetes | 494 (40.6%) | 614 (54.3%) | <0.001 |
| Current cPRA at Transplant | 21.6 (34.1) | 10.0 (22.8) | <0.001 |
| Recipient Pretransplant Dialysis | 1143 (93.8%) | 1018 (90.1%) | <0.001 |
| Recipient Dialysis Duration (months) | 68.4 (49.1) | 34.5 (31.4) | <0.001 |
| Recipient Education Level | 0.378 | ||
| Less than High School | 73 (6.0%) | 60 (5.3%) | |
| High School | 634 (52.1%) | 573 (50.7%) | |
| Some College | 305 (25.0%) | 290 (25.7%) | |
| Completed College | 147 (12.1%) | 136 (12.0%) | |
| Postgraduate Degree | 41 (3.4%) | 51 (4.5%) | |
| Unknown | 18 (1.5%) | 20 (1.8%) | |
| Recipient Prior Malignancy | 122 (10.0%) | 125 (11.1%) | 0.650 |
| Recipient Peripheral Vascular Disease | 148 (12.2%) | 125 (11.1%) | 0.035 |
| Recipient Primary Insurance | <0.001 | ||
| Private | 154 (12.6%) | 272 (24.1%) | |
| Public | 1060 (87.0%) | 857 (75.8%) | |
| Other | 4 (0.3%) | 1 (0.1%) | |
| Donor Age | 39.0 (15.5) | 33.3 (9.1) | |
| Donor Ethnicity | <0.001 | ||
| Caucasian | 788 (64.7%) | 949 (84.0%) | |
| African American | 236 (19.4%) | 51 (4.5%) | |
| Hispanic | 146 (12.0%) | 107 (9.5%) | |
| Asian | 29 (2.4%) | 8 (0.7%) | |
| Other | 19 (1.6%) | 15 (1.3%) | |
| Female Donor | 496 (40.7%) | 411 (36.4%) | 0.031 |
| Donor Height (cm) | 168.3 (18.0) | 172.6 (9.3) | <0.001 |
| Donor Weight (kg) | 82.1 (26.5) | 78.3 (16.5) | <0.001 |
| Donor BUN | 20.6 (15.6) | 17.2 (10.2) | <0.001 |
| Donor Terminal Creatinine | 1.3 (1.1) | 1.0 (0.6) | <0.001 |
| DCD Donor | 259 (21.3%) | 93 (8.2%) | <0.001 |
| Donor Diabetes | 100 (8.2%) | 20 (1.8%) | <0.001 |
| Donor Hypertension | 362 (29.7%) | 150 (13.3%) | <0.001 |
| Donor Blood Type | <0.001 | ||
| A | 184 (15.1%) | 119 (10.5%) | |
| A1 | 239 (19.6%) | 180 (15.9%) | |
| A1B | 15 (1.2%) | 1 (0.1%) | |
| A2 | 26 (2.1%) | 43 (3.8%) | |
| A2B | 7 (0.6%) | 1 (0.1%) | |
| AB | 15 (1.2%) | 8 (0.7%) | |
| B | 153 (12.7%) | 139 (12.3%) | |
| O | 579 (47.5%) | 639 (56.6%) | |
| Donor Vasodilator Use | 142 (11.7%) | 138 (12.2%) | 0.679 |
| Donor Tattoos | 532 (43.7%) | 906 (80.2%) | <0.001 |
| Donor Cigarette Use | 228 (18.7%) | 268 (23.7%) | 0.003 |
| Donor Cause of Death | <0.001 | ||
| Anoxia | 486 (39.9%) | 745 (65.9%) | |
| CVA | 326 (26.8%) | 103 (9.1%) | |
| Trauma | 370 (30.4%) | 264 (23.4%) | |
| Other | 36 (3.0%) | 18 (1.6%) | |
| Cold Ischemia Time (Hours) | 17.3 (8.3) | 18.2 (8.0) | |
| HLA B Mismatches | <0.001 | ||
| 0 | 68 (5.6%) | 26 (2.3%) | |
| 1 | 276 (22.7%) | 277 (24.5%) | |
| 2 | 874 (71.8%) | 827 (73.2%) | |
| HLA DR Mismatches | <0.001 | ||
| 0 | 163 (13.4%) | 65 (5.8%) | |
| 1 | 575 (47.2%) | 460 (40.7%) | |
| 2 | 480 (39.4%) | 605 (53.5%) | |
| Dual Kidney Transplant | 10 (0.8%) | 5 (0.4%) | 0.250 |
| EnBloc Kidney Transplant | 21 (1.7%) | 1 (0.1%) | <0.001 |