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. 2020 Mar 11;40(11):2357–2370. doi: 10.1523/JNEUROSCI.2516-19.2020

Figure 5.

Figure 5.

IFN-β deficiency improves motor and cognitive function recovery after TBI. Beam walk analysis of sham and TBI WT and IFN-β−/− mice. In WT mice TBI induced persistent deficits in fine motor coordination through 28 dpi (p < 0.0001, sham vs TBI; A). In contrast, IFN-β−/− TBI mice had significantly reduced fine motor coordination deficits at 14, 21, and 28 dpi (p < 0.0001, WT TBI vs IFN-β−/− TBI). TBI induces a significant decrease in the percentage spontaneous alternations in the Y-maze task in WT TBI mice compared with WT sham counterparts (p = 0.0134; B), at 8 dpi. In addition, there was no significant difference between groups in the number of entries in each arm of the Y-maze task. To assess nonspatial hippocampal-mediated memory, the NOR task was performed at 18 dpi. TBI mice exhibited a significant decrease in percentage time spent with the novel object compared with sham counterparts (p = 0.0008; C). However, the percentage time IFN-β−/− TBI mice spent with the novel object was comparable to sham animals and spent a significant more percentage of time with the novel object compared with WT TBI mice (p < 0.0001). Data expressed as mean ± SEM. *p < 0.05, ***p < 0.001 versus sham (effect of TBI) and +++p < 0.001 WT TBI versus IFN-β−/− TBI. A, Two-way repeated-measures ANOVA (n = 8–13/group) and (B, C) Two-way ANOVA (n = 8–13/group).