Figure 10.

Effect of chessboard whisker deprivation and the αCaMKII-T286A genotype on lifetime of newly formed and already present spines. A, The survival fraction plot shows that spine lifetimes are briefer in αCaMKII-T286A mice (black line) compared with WTs (gray line). CWD decreases spine survival further in αCaMKII-T286A mice (green line). B, Newly formed spines show similar persistence in chessboard-deprived and undeprived αCaMKII-T286A mice. C, The distribution of spine head sizes is smaller for spines eliminated at the next time point (green line) compared with stable spines (black line). D, Newly formed spines that persist (blue line) have a similar spine size distribution to that of stable spines (black line) in αCaMKII-T286A mice. E, Spine head sizes are smaller in αCaMKII-T286A mice (red) compared with WTs (black); data for undeprived animals. F, Cumulative distribution function for data shown in E. Spines are summed for all cases within each group to form the decay curves.