Figure 7.

Effect of chessboard whisker deprivation on lifetime of newly formed and already present spines. A, Newly formed spines in CWD WT mice (blue line) comprise 18% of initially present spines 1 d following deprivation. The new spine count decays with time to asymptote at ∼8% by 14 d of deprivation. New spines in undeprived WTs only comprise 4% of the total on any given day and decay to ∼1% over the same time period (black line). B, Spines already present at the first observation time point naturally decay over time in undeprived animals (black line) to asymptote at ∼65% of the population after 20 d. CWD (onset shown by arrow) increases the rate of decay (green line) by ∼18% over the same period. Spines summed across all cases in each group.