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. 2020 Mar 11;40(11):2200–2214. doi: 10.1523/JNEUROSCI.1541-19.2020

Figure 5.

Figure 5.

Kv4.1 inhibition reduces K+ current selectively in LF-GCs. A–C, Effects of Kv4.1 antibody on outward K+ currents in LF- and HF-GCs (A), LF-GCs infected by shKv4.1 (B), and CA1-PCs (C). (top) Representative current traces recorded shortly after patch break-in usually within 3 min (marked with 1) and those recorded after 10–15 min (marked with 2). A significant decrease in outward K+ currents by Kv4.1 antibody was observed only in LF-GCs. Voltage protocol was depicted below current traces. (bottom) The current amplitude measured at the peak (Ipeak) normalized to the maximum amplitude during recording period were plotted against the time after patch break-in. D, Ipeak obtained at 15 min after patch break-in normalized to that obtained at 3 min after patch break-in were pooled and plotted as bars with SEM. LF-GCs (n = 15), HF-GCs (n = 8), shKv4.1-infected LF-GCs (n = 7), CA1-PCs (n = 9). Paired t test. ***p < 0.001., N.S. (not significant) p > 0.05.