Table 2. Characteristics of patients allocated to either SPPP or IPPP in the Gd-EOB-DTPA and Gd-DOTA group.
| Pre-scan preparation: Gd-EOB-DTPA | Pre-scan preparation: Gd-DOTA | Gd-EOB-DTPA | Gd-DOTA | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| standard | intensified | p = | standard | intensified | p = | all patients | all patients | p = | ||
| Number of patients | 102 | 108 | 101 | 101 | 210 | 202 | ||||
| Gender | female | 48 (47.1) | 59 (54.6) | 0.273 | 41 (40.6) | 29 (28.7) | 0.052 | 107 (51) | 70 (34.7) | 0.001 |
| male | 54 (52.9) | 49 (45.4) | 60 (59.4) | 72 (71.3) | 103 (49) | 132 (65.3) | ||||
| Age (years) | median (IQR) | 63.4 (52.6–74.0) | 60.9 (53.6–71.5) | 0.538 | 60.7 (52.5–70.5) | 65.0 (53.9–71.5) | 0.225 | 61.7 (53.4–73.4) | 62.8 (53.6–70.9) | 0.851 |
| BMI (kg/m2) ** | median (IQR) | 25.5 (22.2–31.2) | 24.7 (22.5–29.9) | 0.929 | 26.8 (24.7–31.1) | 26.7 (24.6–31.5) | 0.898 | 24.8 (22.4–30.1) | 26.7 (24.6–31.4) | 0.013 |
| Tumor etiology | HCC/CCC | 17 (16.7) | 22 (20.4) | 0.700 | 25 (24.8) | 22 (21.1) | 0.923 | 39 (18.6.3) | 48 (23.8) | <0.001 |
| metastasis | 48 (47.1) | 52 (48.1) | 15 (14.9) | 15 (14.9) | 100 (47.6) | 29 (14.4) | ||||
| no malignancy | 37 (36.2) | 34 (31.5) | 61 (60.3) | 64 (63.3) | 71 (33.8) | 125 (61.9) | ||||
| Acquisition time (s) | 13.0 | 34 (33.3) | 40 (37.0) | 0.854 | 63 (62.4) | 68 (67.3) | 0.461 | 74 (35.2) | 131 (64.9) | <0.001 |
| 14.6 | 50 (49.0) | 50 (46.3) | . | . | 100 (47.6) | 0 (0.0) | ||||
| 17.0 | 18 (17.6) | 18 (16.7) | 38 (37.6) | 33 (32.7) | 36 (17.1) | 71 (35.1) | ||||
| Prior MRI | yes | 56 (54.9) | 63 (58.3) | 0.616 | 64 (63.3) | 63 (62.3) | 0.884 | 119 (56.7) | 127 (62.9) | 0.199 |
| median (IQR) | 2 (1–4) | 2 (1–5) | 0.233 | 2 (1–5) | 2 (1–4) | 0.451 | 2 (1–5) | 2 (1–5) | 0.663 | |
| Prior TSM | yes | 16 (15.7) | 26 (24.1) | 0.129 | . | . | 42 (20) | . | ||
| Pleural effusion | yes | 11 (10.8) | 6 (5.6) | 0.165 | 13 (12.9) | 9 (8.9) | 0.249 | 17 (8.1) | 22 (10.9) | 0.333 |
| < 2cm | 9 (8.8) | 5 (4.6) | >0.999 | 10 (9.9) | 7 (6.9) | >0.999 | 14 (6.6) | 17(8.4) | 0.824 | |
| > 2cm | 2 (2.0) | 1 (0.9) | 3 (3.0) | 2 (2.0) | 3 (1.5) | 5 (2.5) | ||||
| Ascites | yes | 9 (8.8) | 8 (7.4) | 0.707 | 18 (17.8) | 9 (8.9) | 0.048 | 17 (8.1) | 27 (13.4) | 0.083 |
| < 5cm | 7 (6.8) | 6 (5.5) | >0.999 | 16 (15.8) | 7 (6.9) | 0.250 | 13 (6.2) | 23 (11.4) | 0.585 | |
| > 5cm | 2 (2.0) | 2 (1.9) | 2 (2.0) | 2 (2.0) | 4 (1.9) | 4 (2.0) | ||||
| Cirrhosis | yes | 14 (13.7) | 19 (17.6) | 0.442 | 48 (47.5) | 49 (48.5) | 0.500 | 33 (15.7) | 97 (48.0) | <0.001 |
| Lung fibrosis | yes | 3 (3.0) | 6 (5.6) | 0.366 | 3 (3) | 2 (2) | 0.500 | 9 (4.2) | 5 (2.5) | 0.293 |
| CT CM allergy | yes | 4 (9.5) | 2 (4.2) | 0.412 | 1 (1.2) | 3 (3.4) | 0.621 | 6 (2.8) | 4 (2.3) | 0.097 |
| Allergy general ** | yes | 10/52 (19.2) | 12/58 (20.6) | >0.999 | 23 (22.7) | 28 (27.7) | 0.859 | 22/110 (20.0) | 51 (25.2) | 0.476 |
| Cardiac problems ** | none | 7/52 (13.4) | 13/58 (22.4) | 0.502 | 22 (21.8) | 33 (32.6) | 0.056 | 20/110 (18.2) | 55 (26.2) | 0.117 |
Categories are presented as N (%); SD = Standard deviation; IQR = Interquartile range; Mann-Whitney-U Test was used for quantitative data, all other p-values result from a χ2-test for qualitative data (or Fisher's Test if any cell has an expected cell count less than 5); SPPP = standard pre-scan patient preparation; IPPP = intensified pre-scan patient preparation; HCC/CCC = Hepatocellular/ Cholangiocellular carcinoma; BMI = Body mass index; TSM = transient severe respiratory motion; CT CM = CT contrast media; Allergy general = any allergic disposition to substances or food; Cardiac problems = Hypertension, atrial fibrillation, others;
** = Data was not recorded at site A; significant p-values are depicted in bold.