Table 3. Risk factors associated with Gd-EOP-DTPA-related TSM.
| Risk factors | No TSM | TSM | p = | |
|---|---|---|---|---|
| Number of patients | 170 | 40 | ||
| Gender | female | 87 (51.2) | 20 (50.0) | >0.999 |
| male | 83 (48.8) | 20 (50.0) | ||
| Age (years) | median (IQR) | 61.6 (52.6–73.1) | 64.0 (55.9–74.5) | 0.283 |
| Tumor etiology | HCC/CCC | 29 (17.1) | 10 (25.0) | 0.176 |
| metastasis | 80 (47.0) | 20 (50.0) | ||
| no malignancy | 61 (35.9) | 10 (25.0) | ||
| Prior TSM | yes | 27 (15.9) | 15 (37.5) | 0.005 |
| Breath-hold capacity (≥17s) * | yes | 45/58 (77.6) | 13/58 (22.4) | 0.025 |
| median (IQR) | 20 (18.4–20) | 20 (16.6–20) | 0.100 | |
| Pleural effusion | yes | 12 (7.1) | 5 (12.5) | 0.256 |
| Ascites | yes | 14 (8.2) | 3 (7.5) | 0.878 |
| Cirrhosis | yes | 28 (16.5) | 5 (12.5) | 0.535 |
| Lung fibrosis | yes | 7 (4.2) | 2 (5.1) | 0.797 |
| Flow rate (mL/s) | 1 | 85 (50.0) | 15 (37.5) | 0.154 |
| 2 | 85 (50.0) | 25 (62.5) | ||
| Scan time (s) | 17 | 24 (14.1) | 12 (30.0) | 0.064 |
| BMI (kg/m2) ** | 24.9 (22.3–31.0) | 24.8 (22.5–28.0) | 0.622 | |
| CT CM allergy | yes | 4 (2.4) | 2 (5.0) | 0.595 |
| Allergy general ** | yes | 18/85 (21.2) | 4/25 (16.0) | 0.333 |
| Cardiac problems ** | yes | 13/85 (15.3) | 7/25 (28.0) | 0.100 |
Categories are presented as N (%); SD = Standard deviation; IQR = Interquartile range; Mann-Whitney-U Test was used for quantitative data, all other p-values result from χ2-test for qualitative data (or Fisher's Test if any cell has an expected cell count less than 5); HCC/CCC = Hepatocellular/Cholangiocellular carcinoma; TSM = transient severe respiratory motion; CT CM = CT contrast media; BMI = Body mass index; Allergy general = any allergic disposition to substances or food; Cardiac problems = Hypertension, atrial fibrillation, others;
* = Only data from patients at site B with breath-hold training;
** = Data was not recorded at site A; significant p-values are depicted in bold.