Fig 3. Adding parallel paths can further accelerate the EMT process.

(A) Diagram of cell phenotype transition through nine intermediate states with multiple parallel paths. (B) Dependence of FAT distribution on N_pth with three different ΔE values and N_int = 9. (C) Phase diagrams showing MFAT subjected to N_pth and ΔE with N_int = 9. Dashed lines represent two thresholds for monotonic and non-monotonic dependence of MFAT on N_pth. (D) Three typical examples show the monotonic and non-monotonic dependence of MFAT on N_pth according to ΔE value. (E) The dependence of minimal MFAT (blue curve) with a comparison to one parallel path (grey dashed line), and the N_pth the minimum occurs on (red) for ΔE = 6.