Table 2.
Univariate and multivariate analysis of overall survival and recurrent‐free survival in HNSCC patients
| Characteristics | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P value | HR | 95% CI | P value | |
| Overall survival | ||||||
| Age (≥60 y vs <60 y) | 1.318 | 1.003‐1.731 | .047 | 1.223 | 0.891‐1.679 | .214 |
| Gender (female vs male) | 1.349 | 1.014‐1.796 | .04 | 1.372 | 0.978‐1.926 | .067 |
| Smoking history (yes vs no) | 1.123 | 0.803‐1.572 | .498 | |||
| Alcohol history (yes vs no) | 0.942 | 0.709‐1.252 | .68 | |||
| Histologic grade (G3/4 vs G1/2) | 0.867 | 0.637‐1.180 | .419 | |||
| Pathologic stage (III/IV vs I/II) | 1.754 | 1.203‐2.558 | .004 | 1.878 | 1.055‐3.345 | .032 |
| Pathologic N (N1/2/3 vs N0) | 1.86 | 1.343‐2.576 | 1.86E‐04 | 1.422 | 0.973‐2.078 | .069 |
| HPV (positive vs negative) | 0.856 | 0.420‐1.746 | .67 | |||
| P4HA1 expression (high vs low) | 1.775 | 1.358‐2.321 | 2.68E‐05 | 1.728 | 1.267‐2.357 | .001 |
| Recurrence‐free survival | ||||||
| Age (≥60 y vs <60 y) | 1.291 | 0.878‐1.899 | .194 | |||
| Gender (female vs male) | 1.118 | 0.714‐1.751 | .626 | |||
| Smoking history (yes vs no) | 0.973 | 0.626‐1.513 | .904 | |||
| Alcohol history (yes vs no) | 1.809 | 1.130‐2.896 | .014 | 1.36 | 0.827‐2.236 | .226 |
| Histologic grade (G3/4 vs G1/2) | 0.821 | 0.526‐1.281 | .384 | |||
| Pathologic stage (III/IV vs I/II) | 2.302 | 1.249‐4.242 | .007 | 1.514 | 0.721‐3.179 | .274 |
| Pathologic N (N1/2/3 vs N0) | 1.653 | 1.062‐2.573 | .026 | 1.19 | 0.709‐1.996 | .511 |
| HPV (positive vs negative) | 0.914 | 0.343‐2.438 | .858 | |||
| P4HA1 expression (high vs low) | 1.865 | 1.249‐2.785 | .002 | 2.025 | 1.296‐3.162 | .002 |
Abbreviations: CI, confidence interval; HR, hazard ratio.