Figure 4.

An illustration of plasma prolargin and matrix metalloproteinase‐2 (MMP‐2) levels in relation to haemodynamics, heart failure, and pulmonary hypertension. Increasing plasma levels of prolargin and MMP‐2 levels in relation to impaired haemodynamics may inhibit or mediate pathophysiological pathways functional in heart failure and pulmonary hypertension. Hypothetical conclusions are drawn in dotted lines. Red arrows and lines demonstrate deterioration of haemodynamics. LA, left atrial; LV, left ventricular.