Table 3.
Haemodynamic characteristics of patients before and 1 year after heart transplantation
| Haemodynamic parameter | Pre‐HT (n = 26) | Post‐HT (n = 26) | Δ (Post‐HT − Pre‐HT) | P value | |||
|---|---|---|---|---|---|---|---|
| n | Median (IQR) | n | Median (IQR) | n | Median (IQR) | Post‐HT vs. Pre‐HT | |
| MAP (mmHg) | 25 | 82 (77–93) | 26 | 102 (91–108) | 25 | 15 (9–27) | <0.0001* |
| mPAP (mmHg) | 25 | 29 (24–38) | 26 | 14 (12–17) | 25 | −15 (−26 to −7.5) | <0.0001* |
| PAWP (mmHg) | 24 | 20 (18–25) | 26 | 7 (4–9.3) | 24 | −17 (−21 to −6.5) | <0.0001* |
| MRAP (mmHg) | 25 | 14 (7.5–18) | 25 | 3 (1–4) | 24 | −12 (−15 to −3.3) | <0.0001* |
| HR (beats/min) | 25 | 73 (69–82) | 26 | 82 (73–89) | 25 | 7 (−4 to 15) | 0.063 |
| CO (L/min) | 25 | 3.3 (2.6–4.1) | 26 | 5.5 (5–6.5) | 25 | 2.2 (1.2–2.9) | <0.0001* |
| CI (L/min/m2) | 25 | 1.8 (1.4–2.2) | 26 | 2.8 (2.6–3.2) | 25 | 1.1 (0.65–1.6) | <0.0001* |
| SV (mL/beat) | 25 | 48 (35–58) | 26 | 72 (66–78) | 25 | 23 (14–34) | <0.0001* |
| SVI (mL/beat/m2) | 25 | 25 (18–29) | 26 | 36 (33–40) | 25 | 12 (6.5–18) | <0.0001* |
| DPG (mmHg) | 24 | 1 (0–3.8) | 26 | 2 (−0.25 to 4) | 24 | 0 (−2 to 3.5) | 0.8 |
| TPG (mmHg) | 24 | 8.5 (6–12) | 26 | 8 (5–10) | 24 | −1.5 (−6 to 2) | 0.17 |
| PAC (mL/mmHg) | 25 | 2.2 (1.8–3.1) | 26 | 5.4 (4.1–6.6) | 25 | 3.2 (1.3–4) | 0.00029* |
| PVR (WU) | 24 | 2.4 (1.4–3.5) | 26 | 1.4 (0.89–1.9) | 24 | −1.3 (−1.9 to −0.036) | <0.0001* |
| PVRI (WU/m2) | 24 | 5.1 (2.9–6.9) | 26 | 2.8 (1.7–3.7) | 24 | −2.4 (−4 to −0.42) | <0.0001* |
| LVSWI (mmHg × mL/m2) | 24 | 1541 (1052–2007) | 26 | 3344 (3167–3810) | 24 | 1675 (1224–2532) | <0.0001* |
| RVSWI (mmHg × mL/m2) | 25 | 362 (294–615) | 25 | 429 (317–516) | 24 | 62 (−119 to 245) | 0.64 |
| a‐vO2 diff (mL O2/L) | 25 | 74 (63–81) | 23 | 42 (40–51) | 22 | −32 (−40 to −19) | <0.0001* |
| SaO2 (%) | 25 | 96 (94–97) | 23 | 97 (96–98) | 22 | 1.7 (−0.2 to 2.8) | 0.046 |
| SvO2 (%) | 25 | 52 (47–60) | 26 | 69 (66–72) | 25 | 17 (11–24) | <0.0001* |
One cardiac output (CO) value was calculated with indirect Fick before heart transplantation (HT). a‐vO2 diff, arteriovenous oxygen difference; CI, cardiac index; DPG, diastolic pulmonary pressure gradient; HR, heart rate; IQR, interquartile range; LVSWI, left ventricular stroke work index; MAP, mean arterial pressure; mPAP, mean pulmonary artery pressure; MRAP, mean right atrial pressure; PAC, pulmonary arterial compliance; PAWP, pulmonary artery wedge pressure; PVR, pulmonary vascular resistance; PVRI, pulmonary vascular resistance index; RVSWI, right ventricular stroke work index; SaO2, arterial oxygen saturation; SV, stroke volume; SVI, stroke volume index; SvO2, mixed venous oxygen saturation; TPG, transpulmonary pressure gradient; WU, wood units.
Indicates statistically significant values (P < 0.0003; false discovery rate < 0.01).