Table 7.
Haplotype Frequencies of XRCC1 Gene Polymorphisms and Their Association with the Risk of Esophageal Cancer
| Haplotype XRCC1 p.Arg399Gln-p.Arg280His-p.Arg194Trp | Studied Population % (n)(497) | Cases N | Controls | χ2 (p value)* | Odds Ratio (OR)(95% CI) p value** | |
|---|---|---|---|---|---|---|
| G-G-C | 0.501(249) | 0.508(108) | 0.496(141) | 0.1 (p=0.7) | Reference | |
| A-G-C | 0.347(174) | 0.314(67) | 0.372(107) | 3.6 (p=0.05) | 0.82(0.6–1.2) p=0.3 | |
| G-G-T | 0.075(37) | 0.096(20) | 0.058(17) | 5.0(p=0.02) | 1.5(0.7–3.1) p= 0.1 | |
| G-A-C | 0.055(27) | 0.060(13) | 0.052(14) | 0.3(p=0.5) | 1.2(0.5–2.7) p= 0.6 | |
| A-A-C | 0.014(7) | 0.015(3) | 0.014(4) | 0.02(p=0.8) | 0.9(0.2–4.4) p=0.9 | |
| A-G-T | 0.008(4) | 0.007(2) | 0.008(2) | 0.07(p=0.7) | 1.3(0.2–9.4) p=0.8 | |
| LD Measures | Esophageal Cancer Patients | |||||
| D̍̀ | r2 | D̀ | ||||
| p.Arg399Gln-p.Arg194Trp | 0.845 | 0.042 | 0.596 | |||
| p.Arg280His-p.Arg194Trp | 1.0 | 0.009 | 0.969 | |||
| p.Arg399Gln-p.Arg280His | 0.188 | 0.001 | 0.633 | |||
Notes: P* Comparison for esophageal cancer patients and controls for each haplotype. P** Comparison for esophageal cancer patients and controls in comparison to the wild type genotype taken as reference, P<0.05 taken as statistically significant (bold values).