Table 9.
Multifactor Dimensionality Reduction (MDR) Analysis
| Locus Number | Model | Training Balance Accuracy | Testing Balance Accuracy | Cross Validation Consistency | p value* |
|---|---|---|---|---|---|
| 1 | SNP1 | 0.5367 | 0.4965 | 7/10 | 0.37 |
| 2 | SNP1-SNP3 | 0.5494 | 0.4538 | 4/10 | 0.99 |
| 3 | SNP1-SNP3-SNP5 | 0.5621 | 0.4547 | 5/10 | 0.98 |
| 4 | SNP1-SNP2-SNP3-SNP5 | 0.5764 | 0.4289: | 6/10 | 0.98 |
| 5 | SNP1-SNP2-SNP3-SNP4-SNP5 | 0.5905 | 0.4648 | 10/10 | 0.98 |
Notes: SNP1: XRCC1 p.Arg399Gln, SNP2: XRCC1 p.Arg194Trp, SNP3: XRCC1 p.Arg280His, SNP4: XRCC2 Arg188His, SNP5: XRCC2 p.Thr241Met. *p values were based on 1000 permutations.