Key Resources Table

REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Chicken anti-GFP	Invitrogen	Cat #: A10262; RRID: AB_2534023
Rat anti-mCherry	Invitrogen	Cat #: M11217; RRID: AB_2536611
Bacterial and Virus Strains
AAV1-hSyn-GCaMP6f	Penn Vector Core	Addgene 100837
AAV1-hSyn-GCaMP6s	Penn Vector Core	Addgene 100843
AAV8-hSyn-DIO-hM3Dq-mCherry	UNC Vector Core	Addgene 44361
AAV8-hSyn-DIO-hM4Di-mCherry	UNC Vector Core	Addgene 44362
AAV1-DIO-ChR2(H134R)-YFP	Penn Vector Core	Addgene 20298
AAV8-FLEX-TVA-mCherry	UNC Vector Core	Addgene 38044
SADΔG–EGFP (EnvA) rabies	Salk Gene Transfer Targeting and Therapeutics Core	Addgene 32635
AAV8-CaMKII-hM3Dq-mCherry	Addgene	Addgene 50476
Chemicals, Peptides, and Recombinant Proteins
Clozapine-N-Oxide (CNO)	NIMH Drug Supply	Program Cat# C-929
Compound 21 (C21)	Tocris	6422
CNQX	Tocris	Cat# 0190
D-AP5	Tocris	Cat# 0106
Kynurenic Acid	Sigma-Aldrich	Cat# K3375–5G
Picrotoxin	Tocris	Cat# 1128
Bicuculline	Tocris	Cat# 2503
TTX	Tocris	Cat# 1069
4-AP	Sigma-Aldrich	Cat# A78403
Cholera Toxin B Subunit B (Recombinant), Alexa Fluor 555 Conjugate	Thermo Fisher	Cat# 34776
Experimental Models: Organisms/Strains
Mouse: C57BL/6J	The Jackson Laboratory	RRID: IMSR_JAX:000664
Mouse: Nos1-Cre knockin (B6.129-Nos1tm1(cre)Mgmj/J)	The Jackson Laboratory	Strain# 017526; RRID: IMSR_JAX:017526
Mouse: vGlut2-ires-Cre (B6J.129S6(FVB)-Slc17a6tm2(cre)Lowl/MwarJ)	The Jackson Laboratory	Strain# 028863; RRID:IMSR_JAX:028863
Software and Algorithms
MATLAB R2015b, 2019a	Mathworks	https://www.mathworks.com/products/matlab.html; RRID: SCR_001622
MonkeyLogic	Asaad and Eskandar, 2008	http://www.brown.edu/Research/monkeylogic/
MonkeyLogic2	NIMH	https://monkeylogic.nimh.nih.gov/
Scanbox	Neurolabware	https://scanbox.org/
PCA/ICA neuron identification	Mukamel et al., 2009	https://github.com/mukamel-lab/CellSort
Glmnet	Friedman et al., 2010	https://web.stanford.edu/~hastie/glmnet_matlab/
ImageJ 1.49t	NIH	https://imagej.nih.gov/ij/; RRID: SCR_003070