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. 2020 Mar 20;10:5095. doi: 10.1038/s41598-020-61736-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Analysis of oHSV treatment responders vs. non-responders. (a) MRI-measured tumor volumes are plotted with bars separately for vehicle (PBS) and oHSV treatment groups. Tumor volumes before (PRE; blue) and after treatment (POST; red) are plotted with a solid line for increased volumes or dotted line for decreased or unchanged volumes. Individual experimental data and MRI schedule are detailed in Fig. S3,b, e,h. Optical bioluminescent images were captured before and after injection of the appropriate substrate for firefly luciferase (Fluc; b) and renilla (Rluc; c) at multiple-time points in experiment 2. Scatter plots (dot), non-linear regression curve (solid line) and two-sided 95% confidential intervals (shadow) are shown for each graph. oHSV treatment mice were divided in two groups based on tumor responses by MRI from panel a: Non-responder (gray shadow with solid black line) and responder (light red shadow with solid red line). BLI and MRI results of Individual mouse on the time-course are also shown in Fig. S3.