Table 4.
Association of PPARD and PPARG polymorphisms with glioma risk stratified by pathological classification and WHO grade.
| Gene | SNP | Model | Astrocytoma VS. Other glioma | WHO grade (III + IV VS. I + II) |
||||
|---|---|---|---|---|---|---|---|---|
| OR(95%CI) | P | FDR- P | OR(95%CI) | P | FDR- P | |||
| PPARD | rs2016520 | Allele | 0.79(0.64–0.97) | 0.025 | 0.224 | 0.97(0.73–1.28) | 0.810 | 0.989 |
| Co-dominant | 0.60(0.34–1.05) | 0.072 | 0.236 | 1.08(0.50–2.33) | 0.844 | 0.989 | ||
| 0.80(0.61–1.05) | 0.103 | 0.254 | 0.98(0.68–1.41) | 0.923 | 0.992 | |||
| Dominant | 0.77(0.60–1.00) | 0.048 | 0.224 | 0.99(0.70–1.41) | 0.973 | 0.992 | ||
| Recessive | 0.66(0.38–1.14) | 0.135 | 0.315 | 1.09(0.51–2.32) | 0.826 | 0.989 | ||
| Additive | 0.79(0.64–0.97) | 0.027 | 0.224 | 1.01(0.76–1.35) | 0.956 | 0.992 | ||
| PPARD | rs67056409 | Allele | 0.80(0.65–0.98) | 0.033 | 0.224 | 0.93(0.70–1.22) | 0.598 | 0.989 |
| Co-dominant | 0.58(0.34–1.01) | 0.054 | 0.227 | 0.80(0.36–1.77) | 0.584 | 0.989 | ||
| 0.84(0.64–1.10) | 0.198 | 0.362 | 1.03(0.72–1.48) | 0.863 | 0.989 | |||
| Dominant | 0.80(0.62–1.03) | 0.089 | 0.239 | 1.00(0.71–1.42) | 0.992 | 0.992 | ||
| Recessive | 0.63(0.37–1.08) | 0.091 | 0.239 | 0.79(0.36–1.72) | 0.554 | 0.989 | ||
| Additive | 0.80(0.65–0.99) | 0.039 | 0.224 | 0.97(0.73–1.29) | 0.828 | 0.989 | ||
| PPARD | rs1053049 | Allele | 0.76(0.61–0.93) | 0.009 | 0.224 | 0.92(0.69–1.23) | 0.581 | 0.989 |
| Co-dominant | 0.56(0.32–0.98) | 0.043 | 0.224 | 0.87(0.39–1.95) | 0.744 | 0.989 | ||
| 0.77(0.59–1.02) | 0.064 | 0.236 | 0.97(0.67–1.40) | 0.871 | 0.989 | |||
| Dominant | 0.74(0.57–0.96) | 0.024 | 0.224 | 0.96(0.67–1.36) | 0.810 | 0.989 | ||
| Recessive | 0.62(0.36–1.08) | 0.091 | 0.239 | 0.89(0.40–1.95) | 0.762 | 0.989 | ||
| Additive | 0.76(0.62–0.94) | 0.012 | 0.224 | 0.95(0.71–1.28) | 0.754 | 0.989 | ||
| PPARD | rs2206030 | Allele | 1.09(0.91–1.31) | 0.342 | 0.497 | 1.08(0.85–1.38) | 0.510 | 0.989 |
| Co-dominant | 1.18(0.82–1.70) | 0.376 | 0.497 | 1.14(0.69–1.88) | 0.615 | 0.989 | ||
| 1.09(0.81–1.48) | 0.572 | 0.632 | 1.38(0.91–2.10) | 0.131 | 0.523 | |||
| Dominant | 1.12(0.84–1.49) | 0.447 | 0.539 | 1.30(0.88–1.94) | 0.192 | 0.620 | ||
| Recessive | 1.12(0.82–1.52) | 0.489 | 0.555 | 0.92(0.61–1.39) | 0.684 | 0.989 | ||
| Additive | 1.09(0.91–1.30) | 0.372 | 0.497 | 1.08(0.84–1.38) | 0.560 | 0.989 | ||
| PPARG | rs2920503 | Allele | 0.91(0.75–1.12) | 0.379 | 0.497 | 1.27(0.98–1.64) | 0.074 | 0.499 |
| Co-dominant | 0.92(0.57–1.49) | 0.744 | 0.801 | 2.04(1.13–3.68) | 0.018 | 0.378 | ||
| 0.85(0.65–1.11) | 0.235 | 0.386 | 1.02(0.70–1.47) | 0.933 | 0.992 | |||
| Dominant | 0.86(0.67–1.11) | 0.255 | 0.397 | 1.17(0.83–1.65) | 0.377 | 0.989 | ||
| Recessive | 0.99(0.63–1.58) | 0.982 | 0.982 | 2.03(1.15–3.57) | 0.014 | 0.378 | ||
| Additive | 0.91(0.75–1.12) | 0.370 | 0.497 | 1.27(0.98–1.64) | 0.074 | 0.499 | ||
| PPARG | rs4073770 | Allele | 1.02(0.85–1.24) | 0.818 | 0.838 | 0.80(0.62–1.03) | 0.083 | 0.499 |
| Co-dominant | 0.86(0.56–1.31) | 0.480 | 0.555 | 0.70(0.38–1.27) | 0.240 | 0.672 | ||
| 1.28(0.98–1.69) | 0.073 | 0.236 | 0.73(0.51–1.06) | 0.095 | 0.499 | |||
| Dominant | 1.18(0.91–1.53) | 0.211 | 0.369 | 0.73(0.51–1.03) | 0.071 | 0.499 | ||
| Recessive | 0.76(0.51–1.13) | 0.170 | 0.340 | 0.82(0.46–1.45) | 0.489 | 0.989 | ||
| Additive | 1.03(0.85–1.24) | 0.799 | 0.838 | 0.80(0.61–1.04) | 0.092 | 0.499 | ||
| PPARG | rs1151988 | Allele | 0.83(0.64–1.08) | 0.160 | 0.340 | 1.25(0.88–1.78) | 0.209 | 0.627 |
| Co-dominant | 0.62(0.21–1.88) | 0.403 | 0.513 | 1.54(0.34–7.05) | 0.580 | 0.989 | ||
| 0.84(0.62–1.13) | 0.239 | 0.386 | 1.34(0.90–2.00) | 0.154 | 0.539 | |||
| Dominant | 0.82(0.61–1.10) | 0.191 | 0.362 | 1.35(0.91–2.00) | 0.137 | 0.523 | ||
| Recessive | 0.65(0.22–1.97) | 0.449 | 0.539 | 1.43(0.31–6.52) | 0.646 | 0.989 | ||
| Additive | 0.83(0.63–1.08) | 0.164 | 0.340 | 1.32(0.92–1.90) | 0.137 | 0.523 | ||
SNP, single nucleotide polymorphism; MAF, minor allele frequency; HWE, Hardy-Weinberg equilibrium; OR, odds ratio; CI, confidence interval; FDR, false discovery rate.
Bold values indicate statistical significance (P < 0.05).