Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Mar 20;10:5088. doi: 10.1038/s41598-020-61714-8

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Tertiary structures of PZP and A2ML1. The structure of human PZP was predicted based on published amino acid sequences (NP_002855.2 and P20742) (A). A2M_N: Macroglobulin domain of alpha-2-macroglobulin; A2M_N_2: Alpha-2-macroglobulin family N-terminal region; A2M: Alpha-2-macroglobulin family C-terminal region; A2M_comp: A-macroglobulin complement component; A2M_recep: A-macroglobulin receptor; BAIT region: protease binding regions; Thiol-ester site: sequence that shows conformational change after protease binding; S-S: disulfide moiety; boxed numerals (1–36): exon number; 400-800-1200-1400: amino acid location. I: Amino acid sequence upstream of bait region; II: amino acid sequence of bait region; III: amino acid sequence downstream of C-terminal region after the bait region. Panels B–F: Predicted tertiary structures of human PZP dimer (B), human PZP monomer (C), human A2ML1 monomer (D), marmoset PZP monomer (E), and marmoset A2ML1 monomer (F). Different areas are represented by the following colours: Bait region, white; Proline-endopeptidase cutting site, pink; Aspartic acid-N endopeptidase cutting site, black; LysC, orange; LysN, yellow.