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Genetic stability of viruses following serial passage in Vero cells.
| Viral gene | Nucleotide positiona | Variant | Coding impact | Variant percentageb | |
|---|---|---|---|---|---|
| Sabin OPV2 | nOPV2-CD | ||||
| None (5′ UTR) | 156 | T to C | None | — | 7.5 |
| None (5′ UTR) | 481 | A to G | None | 18.6 | — |
| VP1 | 2797 | T to A | S106T | 13.3 | — |
| 3 C | 5774 | A to T | Y113F | 77.1 | 11.3 |
aPosition designation based on Sabin-2.
bVariants greater than 5% reported.
