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. 2020 Mar 20;10:5163. doi: 10.1038/s41598-020-62136-2

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effects of EGCG and nano-EGCG on the activation of MMP-2 and MMP-9 in lung cancer cells. (A) H1299 and CL1-5 cells were treated with EGCG in serum-free medium for 24 hours, and the activity of MMPs was analyzed through a gelatin zymography assay. (B) H1299 and (C) A549 cells were treated with different concentrations of nano-EGCG before the subsequent zymography assay.