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. 2020 Mar 20;10:5161. doi: 10.1038/s41598-020-61958-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Profiling of the microarray data: (a) Scatter plot is performed to visualize the expression variation of differentially expressed miRNAs between NPC with different radiosensitivity. The values of X and Y axis are log2 scaled intensity values of miRNA microarray probes. Red color implies miRNAs in higher expression level and green one signifies miRNAs in lower expression level. (b) Volcano plot is presented to show significantly differentially expressed miRNAs (P < 0.05). Fold change values are log2 transformed as the X axis while the log10 transformation of P values are set in the Y axis. (c) Hierarchical clustering is conducted to show the expression patterns of differentially expressed miRNAs in 12 samples.