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. 2020 Mar 20;10:5113. doi: 10.1038/s41598-020-61918-y

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Gene ontology and STRING analysis of differentially regulated proteins of C. albicans upon oleic acid treatment. (a) Gene ontology analysis of differentially regulated (both up regulated and down regulated) proteins using UniProt database. The differentially expressed proteins are mainly involved in cellular process (37%), catalytic activity (33%), metabolic process (30%), binding (29%), response to stimulus (9%), biological regulation (8%), and cellular component organization (7%) (b) Protein-protein interaction prediction map of (i) down regulated and (ii) up regulated proteins of C. albicans obtained using STRING v.11 database (confidence score 0.400). The interaction map shows the proteins involved in interrelated pathways such as proteasome, spliceosome, carbon metabolism, biosynthesis of antibiotics, biosynthesis of secondary metabolites and metabolic pathways. Filled protein nodes that signify the availability of protein 3D structural information is known or predicted.