Fig. 3.

E-cadherin activation reduces the metastatic colonization from circulation. (A) Schema. Mouse epithelial 4T1 Luc-hE cells were injected into the tail-vein of BALB/c mice. One day after inoculation, the mice were treated with i.p. injections of either 46H7 neutral or 19A11 activating mAb twice weekly until the end of the experiments. (B) Representative microscopic images of H&E stained sections (Top) or lungs fixed with Bouin’s (Bottom). (C) Quantification of metastatic tumor nodules (n = 15). (Scale bar, 500 μm.) **P < 0.01 compared with neutral Ab-treated control group.