Fig. 3.
Overlapping regulons of major PCWDE regulators in N. crassa. Plot built with Circos, version 0.69 (80), to display positive regulation of catabolic CAZymes by indicated transcription factors (red) derived from the identification of genes that showed differential expression of 21.5-fold between WT and transcription factor mutant (Dataset S1). CAZymes are divided into functional groups displayed on the outer edge of the plot. Ar, arabinose; Ar. cat., arabinose catabolism; β-glu, β-glucosidases; β-m, β-mannanases; Pec. cat, pectin catabolism; PMO, polysaccharide monooxygenases; Xy, xylose. Each CAZyme is represented by its gene ID. Each line represents genes with significantly different expression between WT and a transcription factor deletion mutant under the following conditions: ∆clr-1 and ∆clr-2 shifted to 1% Avicel, ∆col-26 shifted to 2 mM maltose (19), ∆pdr-1 shifted to 1% pectin (11), ∆pdr-2 shifted to 1% citrus peel, ∆ara-1 shifted to 1% Miscanthus, and ∆xlr-1 shifted to 1% xylan (Dataset S4). The thickness of the line corresponds to degree of fold change in the transcription factor deletion mutants compared to WT cells (11, 19), with thicker lines indicating a higher fold change.