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Illustration of SS1P in the kidney tubule. SS1P is filtered through glomerular and accumulated in the proximal tubule. It can be uptake by the tubule cells through endosome and degraded in the lysosome. Some portion of albumin is also filtered by PTCs, binds to megalin/cubilin, and undergoes transcytosis. PTCs are damaged by SS1P and have a decreased ability to absorb or transcytose albumin leading to more albumin in the urine. Lysine can compete with SS1P and reduced SS1P uptake.
