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. 2020 Feb 28;117(11):6042–6046. doi: 10.1073/pnas.1918950117

Fig. 1.

Fig. 1.

Genetic disruption of pQa-1–TCR interaction enhances TFH and B cell responses upon heart transplantation. (A) Single-dose CTLA4-Ig heart transplant protocol using BALB/c heart allograft and C57BL/6 (WT) recipient. Comparison of Qa-1 MFI by total CD4 (blue) and (B) CD4 TEM (CD62L–CD44+CD4+) (red) and (C) TFH (PD-1+CXCR5+CD4+) (red) in recipient spleens at day 28 post heart transplantation (n = 5; unpaired t test). Analysis of lymphocyte subsets frequency including TEM (D) and TFH (E), as well as isotype-switched germinal center B cells (IgM−FAS+B220+) (F), and plasma cells (B220−CD138+) (G) in spleens of BALB/c heart allograft recipients under single-dose CTLA4-Ig protocol at day 28 (n = 6/group; unpaired t test). MFI: mean fluorescence intensity. *P < 0.05; **P < 0.01; ***P < 0.001.