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. 2020 Mar 2;117(11):5923–5930. doi: 10.1073/pnas.1921381117

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Fig. 4. — Cyp2c44 and the prostaglandin profile. (A) Tumors were isolated from 20-wk-old PyMT and PyMT^Δ2c44 (Δ2c44) mice and prostaglandin (PG) levels assessed by LC-MS/MS; n = 7 mice per group (Student’s t test). (B) PGE₂ and 12-HHT levels in liver microsomes from wild-type (WT) and Cyp2c44^−/− (^−/−) mice, n = 6 independent experiments, each performed in triplicate (Student’s t test). (C) PGE₂ and 12-HHT levels in microsomes from Cyp2c44-deficient (CTL) and Cyp2c44-expressing (2c44) Sf9 cells in the presence of PGH₂. n = 6 independent experiments, each performed in triplicate (Student’s t test). *P < 0.05; **P < 0.005; ***P < 0.001.