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. 2020 Mar 2;117(11):5923–5930. doi: 10.1073/pnas.1921381117

Fig. 5.

Fig. 5.

Link between Cyp2c44 deletion and WDFY1. (A) Volcano blot showing the proteins most altered in tumors from PyMTΔ2c44 (Δ2c44) versus PyMT mice. (B) WDFY1 expression (Log2 LFQ intensity) from the proteomics data set; n = 7 animals per group (Student’s t test). (C) WDFY1 mRNA expression from an independent series of tumors; n = 6 animals per group (Student’s t test). (D) WDFY1 and NRP protein levels normalized to nonmuscle myosin (NMM) in similarly sized primary tumors from PyMT and PyMTΔ2c44 mice; n = 6 animals per group (Student’s t test). (E) WDFY1 and NRP protein levels in similarly sized primary tumors from PyMT and PyMTΔ2c44 mice. (Insets) Magnifications of the areas marked by boxes. (Scale bar = 5 µm; Upper, bar = 2 µm.) (Lower) n = 12 animals per group (Student’s t test). *P < 0.05; ***P < 0.001.